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Few scientific dilemmas in the beginning of the third decade of the 21st century, are still not investigated in an integral comprehensive approach compatible with the era scientific advances. Human Consciousness, its origin, nature and the delicate symphony orchestrating its execution remains at the top of the list of the elusive sciences of the human history. Intuitively, our ancestors refer to the human heart as the seat of soul and the center of the consciousness experience. The scientific evidence of this miraculous issue must be life time struggle but scientistists in quantum physics, cardiac astrophysics, mathematics and computational engineering in the last 8 decades started to decode the miraculous mystery. Five international conferences, King of Organs Conferences (KOO) chaired by the author of this review were held (King of Organs International Conferences for Advance Cardiac Sciences in 2006, 2008, 2010, 2012 and 2019) with collaboration of collective group of world leaders in cardiac astrophysics, stress, heart math, chronobiology, mathematics, geology and space sciences. The great collective mission was to navigate in consciousness scientific aspects. KOO series of conferences started in 2006, incorporated up to date scientific understandings in the field of consciousness in the last 80 years, with unique and special scientific direction considering the human heart as central operator in the consciousness experience. Escalating accumulation of scientific evidences of what was thought of as intuitive concepts about the human heart role of consciousness had became evident, the dawn of which emerged in respectful publications from KOO and scientific collaborates research. There is compelling scientific and rational evidence to convince scientific communities that the nature of consciousness involves dynamics inside the skull but essentially much beyond it in extreme dimensions between the skull and the sky. The approach we adopted is based on holistic perspective and understanding of human consciousness incorporating quantum physics, cardiac astrobiology, mathematics, neurocardiology, and other disciplines in addition to philosophical bases of consciousness.