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Toward the end of the second decay of the 21st century cardiovascular diseases are still rank first cause of death across planet nations. In spite of the explosive scientific advances of the 20th century and after, it is now conspicuous that sincere call for wisdom is highly needed. Major changes in the methodology and basic understanding and execution of medical research is a must. The medical and pharmaceutical industry should have no connection or contribution to medical research in the new era. Devout and ascetic scientific groups representing the world nations should act as anew union to establish the new pillars for cardiovascular practice and research. Major corrective steps in our understanding of cardiovascular disease should be adopted. Prioritizing the future directions is of paramount importance. New epidemic of diseases affecting the heart and other body organs due to current pharmaceutical trends must be thought of immediately. The shock brought by today medical literature related to the serious suspicions of cholesterol theory and the documented harms of station medications deserve urgent actions. Kilmer McCully theory in 1969 establishing the role of hyper-homocycteinemia to atherosclerosis has grown up in the last 47 years to include wide spectrum of pathologies creating major health as well as psychosocial burden in human communities. It is time to turn our attention to Kilmer McCully nutritional protocol and others to enhance the quantum therapeutic effects of human body to treat it self-utilizing the native body biochemistry pathways away from the accumulated pharmacological toxicities. Epigenetic mechanisms in relation to cardiovascular diseases include DNA methylation, histone modification, and microRNA alterations, which collectively enable cardiac cell to respond quickly to environmental changes should be enhanced to treat cardiovascular and other human diseases in isolation from the medical industry and the economic language.