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Personalized chronobiologic cybercare; other chronomics’ progress by transdisciplinary cycles’ congruences: season’s appreciations 2009

Franz Halberg, Germaine Cornélissen, Patricia Grambsch, Rollin McCraty, Larry Beaty, Jarmila Siegelová, Pavel Homolka, Dewayne Carol Hillman, Judy Finley, Faithe Thomas, Tomoshige Kino, Miguel Revilla, Othild Schwartzkopff

Journal of Applied Biomedical 9:1-34, 2011.

For a PDF version of the complete paper, click here.

Summary

Originally a remembrance of an elderly physiologist, this paper illustrates the need for a standardized specification of certain experimental or survey conditions beyond those usually necessarily disclosed in conventional publications, namely calendar-dates, clock-times and geographic locations, to allow reference to helio-ionosphero-geomagnetics along with natural and artificial lighting and temperature. When possible, body times given by a marker rhythm also should be specified. A personalized chronobiologic cybercare can eventually include focus on infradians, beyond circadians. Benefits from longitudinal monitoring are:

  1. Chronobiologically-interpreted blood pressure (BP) and heart rate (HR) monitoring enables the diagnosis and treatment of Vascular Variability Anomalies (VVAs) or, if lasting in several 7-day records, Disorders (VVDs), not yet screened for in practice, that increase cardiovascular disease risk independently of an elevated BP.
  2. The optimal treatment time for the individual patient can be determined and potential harm avoided, since the same dose of the same medication for the same patient can help or harm depending only on when it is administered.
  3. Benefit may be derived in cancer treatment timed according to marker rhythmometry.
  4. The change from a spotcheck-based health care to one of internet-aided systematic self-surveillance by the automatic collection and analysis of time series stems from evidence that nonphotic and photic environmental influences affect biota, associations that may depend on geographic and temporal location.
  5. Imaging in time includes formatting for time, globally and locally, for the mapping of a transdisciplinary spectrum of cycles involving “good” and “bad” strain in human physiology, versus sudden cardiac death, suicide and terrorism, all latter requiring rational countermeasures.